Microfluidics in Focus: The Power of Structured Functionalization

Posted by:
Alexis Tzannis
Published on:
Sep 2, 2025
The field of microfluidics has revolutionized liquid handling on the microscale, enabling cost-effective, portable devices. In the final part of our four-part series, discover how to select and optimize structured surface functionalization methods.
This article covers:
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Core methods such as silanization, PEGylation, and click chemistry
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Advanced patterning techniques including lithography, CVD, and aerosol jet printing
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How structured surfaces enable multiplex analyte detection with high sensitivity and throughput
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Key challenges like material compatibility, non-specific binding, and scalability — and practical solutions to address them
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Case studies showing how these technologies are shaping diagnostics and organ-on-chip platforms
It’s a comprehensive guide full of insights and real-world examples that point to the future of microfluidics.
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Microfluidics Expert Alexis Tzannis
Alexis holds a PhD in physical chemistry from ETH Zürich, is fluent in four languages, and has a proven record of forging academia–industry partnerships to accelerate innovation. A founding member of the Microfluidics Association (MFA), he is a micro- and nanotechnology business leader with 15 years of experience taking microfluidic products from concept to industrialization.
Alexis has delivered double-digit sales growth at HSE•AG and previously at IMT Microtechnologies by leading cross-functional teams and cultivating global key accounts. His technical expertise spans the design and manufacture of glass, silicon, and hybrid-material microfluidic platforms that enable cutting-edge analytical applications, e.g., next-generation sequencing (NGS) and others.